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Article

HFpEF as the predominant and underrecognized heart failure phenotype in type 2 diabetes: evidence from the DIABET-IC study.

Cardiovascular diabetology - 3 Nov 2025

Gil-Millan P, Gimeno-Orna J A, Rodriguez-Padial L, Muniz J, Barrios V, Anguita M, Perez A

Abstract excerpt

BACKGROUND: Heart failure (HF) is a major complication of type 2 diabetes (T2D), with HF with preserved ejection fraction (HFpEF) now representing the most frequent phenotype. However, its clinical profile, prognosis, and treatment patterns compared with HF with reduced ejection fraction (HFrEF) remain insufficiently characterized. OBJECTIVES: To compare characteristics, outcomes, and longitudinal management of...

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Topics

Humans
Female
Diabetes Mellitus, Type 2
Male
Heart Failure
Phenotype
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Stroke Volume

Middle Aged

Prospective Studies

Time Factors

Risk Factors

Spain

Ventricular Function, Left

Prevalence

Treatment Outcome

Disease Progression

Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 41185008
DOI: 10.1186/s12933-025-02995-z
PMCID: PMC12581349

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