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Article

Joint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort.

RMD open - 29 Oct 2025

de Maleprade Baptiste, Jastrzebski Fabien, Benhamou Ygal, Sauvetre Gaetan, Membrey Benjamin, Avenel Marine, Curie Alexandre, Armengol Guillaume, Brevet Pauline, Langlois Vincent, Lequerre Thierry, Stamatoullas-Bastard Aspasia, Jardin Fabrice, Vittecoq Olivier

Abstract excerpt

OBJECTIVE: To describe the joint manifestations associated with clonal haematopoiesis and to compare patients with and without VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. METHODS: Patients screened for UBA1 mutations between December 2019 and January 2023 in 7 Normandie (France) hospitals were recruited retrospectively. RESULTS: Thirty patients with a haematological disorder...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41167634
DOI: 10.1136/rmdopen-2025-006074
PMCID: PMC12574337

Genes

UBA1
ASXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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