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Article

Impact of next-generation sequencing on routine clinical practice and patient inclusion in molecularly targeted clinical trials: a retrospective cohort analysis.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2026

Faigner Mathieu, Karayan-Tapon Lucie, Cortes Ulrich, Ndiaye Birama, Martel Marine, Rivet Pierre, Duche Jade, Isambert Nicolas, Tougeron David, Evrard Camille

Abstract excerpt

BACKGROUND: High-throughput sequencing has advanced biomarker identification, enabling more targeted cancer treatment. Various gene panels are used to screen for actionable genomic alterations for clinical practice and trial inclusion. OBJECTIVES: We aimed to determine the proportion of cancer patients with a targetable molecular tumor alteration and their inclusion in related trials using a routine panel, and to...

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Identifiers

PMID: 41160368
DOI: 10.1007/s12094-025-04086-7
PMCID: PMC13008994

Genes

BRAF
KRAS
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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