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Article

Role of the alpha-1 antitrypsin in the progression and severity of COVID-19 infection among Saudi patients.

BMC infectious diseases - 28 Oct 2025

Ali Rabab A, Mohammedsaeed Walaa A, Fakher Mohamed Hisham A, Noor Hala K, Al Qurashi Yasir M

Abstract excerpt

BACKGROUND: Alpha-1 antitrypsin (A1AT) is involved in pathophysiology of severe COVID-19, including thrombosis expansion. A1AT has anti-inflammatory, tissue-protective, and anticoagulant capabilities. We aimed to screen frequencies of A1AT gene polymorphism among COVID-19 Saudi patients and its relation to severity. METHODS: Through cross-sectional study, we examined 100 COVID-19 Saudi patients to explore...

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PMID: 41152707
DOI: 10.1186/s12879-025-11699-4
PMCID: PMC12570426

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