A novel MRI diffusion metric 'slow diffusion coefficient' (SDC) for diagnosing isocitrate dehydrogenase (IDH) genotype in diffuse gliomas: initial promising results.

Abstract excerpt

BACKGROUND: Determining isocitrate dehydrogenase (IDH) mutation is crucial for glioma management. Slow diffusion coefficient (SDC) is a novel metric being proposed to measure in vivo tissue slow diffusion. In its basic form, SDC is derived from a high b-value diffusion-weighted image and a higher b-value diffusion-weighted image. The study attempts to distinguish IDH genotypes of diffuse gliomas using SDC alone...

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