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Article

Genotype-guided dual antiplatelet therapy in minor stroke or transient ischemic attack with metabolic syndrome: A post hoc analysis of CHANCE-2.

Diabetes, obesity & metabolism - 1 Jan 2026

Feng Zhiyuan, Zhang Fangyuan, Jin Aoming, Li Xinchen, Li Yimeng, Chu Qi, Xue Jing, Cheng Aichun, Lin Jinxi, Li Hao, Meng Xia, Wang Yongjun, Xu Jie

Abstract excerpt

AIMS: To evaluate the relationship between metabolic syndrome and the efficacy and safety of genotype-guided dual antiplatelet therapy (DAPT) in the CHANCE-2 trial. MATERIALS AND METHODS: This post hoc study used data from the CHANCE-2 trial. Patients with minor stroke or TIA who carried the CYP2C19 loss-of-function (LOF) allele were randomized to receive ticagrelor-aspirin (TIC-ASA) or clopidogrel-aspirin...

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Identifiers

PMID: 41145384
DOI: 10.1111/dom.70243

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CYP2C19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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