Article
Growth Hormone Assay-Adjusted Standardization Reveals Distinct Clinical Phenotypes in Acromegaly.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists - 1 Feb 2026
Biagetti Betina, Marques Pedro, Ferrer Roser, Cardoso Luís Miguel, Moreno Eva Venegas, Fajardo-Montañana Carmen, Gonzalez-Fernandez Laura, Pérez Pena Marta María, García-Centeno Rogelio, Lozano-Aida Claudia, Novoa-Testa Iría, Pascual-Corrales Eider, Sánchón Raúl, Guerrero-Pérez Fernando, Rodríguez Rosario Oliva, Jiménez Beatriz Rodríguez, Ollero García María Dolores, Echarri Ana Irigaray, Simó-Servat Andreu, Moure Rodríguez María Dolores, Calatayud María, Villar-Taibo Rocío, Tenorio-Jimenéz Carmen, Novo-Rodríguez Cristina, Molero Inmaculada González, Iglesias Pedro, Blanco Concepción, Vidal-Ostos De Lara Fernando, Aulinas Anna, Asla Roca Queralt, Paja Miguel, Abellán Galiana Pablo, Cordido Fernando, Menéndez Torre Edelmiro, Cámara Rosa, Sarria-Estrada Silvana, Aznar Rodríguez Silvia, Lamas Cristina, Alvarez-Escola Cristina, Bernabéu Ignacio, Hanzu Felicia, Marazuela Mónica, Puig-Domingo Manel, Araujo-Castro Marta
Abstract excerpt
OBJECTIVE: To identify distinct clinical phenotypes in acromegaly based on growth hormone (GH) assay standardization and unsupervised machine learning. METHODS: This was a multicenter cross-sectional analysis of 416 patients diagnosed with acromegaly from 2010 onward. Patients were stratified according to baseline serum GH levels standardized to the assay-specific upper limit of normal (GHxULN) using a binary...
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