High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing.

doi:10.1182/blood.2025029999

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Article

High-risk genomic consensus validation for patients with newly diagnosed multiple myeloma using next-generation sequencing.

Blood - 15 Jan 2026

Schavgoulidze Anaïs, Perrot Aurore, Leleu Xavier, Cazaubiel Titouan, Chretien Marie-Lorraine, Feugier Pierre, Belhadj Karim, Manier Salomon, Roussel Murielle, Brechignac Sabine, Orsini-Piocelle Frédérique, Mohty Mohamad, Schiano de Collela Jean-Marc, Macro Margaret, Adiko Didier, Dib Mamoun, Fontan Jean, Luttiau-Motard Carine, Bouscary Didier, Pascal Laurent, Roland Virginie, Lifermann François, Bakala Jana, Montes Lydia, Kennel Céline, Rey Philippe, Richez Valentine, Keddar Faiza, Frenzel Laurent, Calmettes Claire, Chaleteix Carine, Plantier Isabelle, Chalayer Emilie, Schmitt Anna, Roul Christophe, Demarquette Hélène, Cerutti Chloe, Pavageau Luka, Derrier Laure, Avet-Loiseau Hervé, Corre Jill

Abstract excerpt

ABSTRACT: The prognostic heterogeneity of multiple myeloma is mainly driven by the genomic features of myeloma cells. The International Myeloma Society (IMS)/International Myeloma Working Group (IMWG) recently proposed a high-risk (HR) genomic model to have a consensus definition of genomic risk. We performed next-generation sequencing in the form of a panel on samples from 6528 patients with newly diagnosed...

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PMID: 40991836
DOI: 10.1182/blood.2025029999
PMCID: PMC13292120

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TP53

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