Article
Association of Genetic Predisposition to Inflammation With Cancer-Related Cognitive Impairment and Fatigue in Women Who Received Chemotherapy for Nonmetastatic Breast Cancer.
JCO precision oncology - 1 Sept 2025
Olowofela Ayokunle S, Auer Paul L, Janelsins Michelle, Mustian Karen, Conlin Alison, Onitilo Adedayo A, Melnik Marianne, Li Chin-Shang, Gada Umang, Sun Hongying, Kerns Sarah L
Abstract excerpt
PURPOSE: Cancer-related cognitive impairment (CRCI) and cancer-related fatigue (CRF) are reported by approximately 75% of patients receiving chemotherapy for breast cancer and both have been linked to inflammation. We sought to test whether an inflammation polygenic risk score (iPRS) might be associated with CRCI and/or CRF. METHODS: Using data from the UK Biobank, we developed an iPRS for the INFLA-Score, a...
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