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Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study

12 Mar 2019

Abstract excerpt

BACKGROUND: Little is known about the effects of chemotherapeutic drugs on DNA methylation status of leukocytes, which may be predictive of treatment benefits and toxicities. Based on a prospective national study, we characterize the changes in leukocyte DNA methylome from pre- to post-chemotherapy (approximately 4 months apart) in 93 patients treated for early stage breast cancer and 48 matched non-cancer...

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PMID: 30867049
DOI: 10.1186/s13148-019-0641-1

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