Article
The X-Linked TLR7 rs179008 T Allele Is Associated with an Increased Risk of Severe Multisystem Inflammatory Syndrome in Children/Kawasaki-like Syndrome in SARS-CoV-2-Infected Boys.
International journal of molecular sciences - 1 Sept 2025
Andrade Adriana de Souza, Bentes Aline Almeida, Diniz Lilian Martins, Hees Carvalho Silvia, Kroon Erna Geessien, Campos Marco Antonio
Abstract excerpt
The X-linked TLR7 rs179008 T allele has been associated with altered antiviral immunity. Given their shared inflammatory pathways and higher pediatric mortality rates in Brazil during the pandemic, we investigated their association with multisystem inflammatory syndrome in children (MIS-C) together with Kawasaki disease (KS) following SARS-CoV-2 infection. A cross-sectional study (2021-2022) analyzed 73...
Read the complete abstract on PubMedTopics
- Humans
- COVID-19
- Male