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Dissemination of OXA-23 carbapenemase-producing Proteus mirabilis and Escherichia coli is driven by transposon-carrying lineages in the UK.

Microbial genomics - 1 Sept 2025

Zamudio Roxana, Osman Karen, Pike Rachel, Chaudhry Aiysha, Meunier Danièle, Stoesser Nicole, Stretch Rebecca, Turton Jane F, Williams David, Hopkins Katie L

Abstract excerpt

Carbapenem-resistant Enterobacterales are a significant threat to global public health. Here, we characterize bla OXA-23-positive Proteus mirabilis (n=8) and Escherichia coli (n=3) isolates from human clinical samples collected between 2021 and 2024 in the UK. Whole-genome sequencing (WGS) was used to generate data, and a phylogenetic tree inferred from SNPs filtered for recombination was constructed to assess...

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Identifiers

PMID: 40934106
DOI: 10.1099/mgen.0.001502
PMCID: PMC12426204

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