C3 p.Asp1115Asn Variant-associated Atypical Hemolytic Uremic Syndrome with Spontaneous Remission Triggered by Influenza and COVID-19.

doi:10.2169/internalmedicine.6036-25

Article

C3 p.Asp1115Asn Variant-associated Atypical Hemolytic Uremic Syndrome with Spontaneous Remission Triggered by Influenza and COVID-19.

Internal medicine (Tokyo, Japan) - 15 Apr 2026

Fujino Yudai, Hanada Hinako, Takata Tomoaki, Kageyama Kana, Taniguchi Sosuke, Mae Yukari, Hoi Shotaro, Iyama Takuji, Watanabe Akinori, Sasaki Sho, Tsunoda Shinichiro, Morishima Atsuyuki, Isomoto Hajime

Abstract excerpt

The clinical manifestations of atypical hemolytic uremic syndrome (aHUS) vary depending on the genetic background. A 19-year-old man with the C3 p.Asp1115Asn variant experienced 2 episodes of recurrent aHUS following respiratory tract infections caused by influenza and coronavirus disease 2019 (COVID-19). The patient's symptoms spontaneously remitted without plasma exchange or eculizumab treatment in both...

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C3 p.Asp1115Asn Variant-associated Atypical Hemolytic Uremic Syndrome with Spontaneous Remission Triggered by Influenza and COVID-19.

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