Article
Aplf/Dna2 variants drive chromosomal fission and accelerate speciation in zokors.
Science advances - 5 Sept 2025
Wan Na, Duan Qijiao, Cai Zhenyuan, Zhu Zhanwu, Wang JingOu, Tian Yonghui, Shen Wei, Li Bowen, Kuang Zhuoran, Liang Xiaolong, Liu Sanyuan, An Xuan, Yang Xiaojie, Liu Xi, Mao Leyan, Chen Jiaqi, Wang Yinjia, Feng Zhilong, Liu Wenwen, Bu Yueting, Nevo Eviatar, Papa Riccardo, Meyer Axel, Liu Jianquan, Li Kexin
Abstract excerpt
Chromosomal fissions and fusions are common, yet the molecular mechanisms and implications in speciation remain poorly understood. Here, we confirm a fission event in one zokor species through multiple-omics and functional analyses. We traced this event to a mutation in a splicing enhancer of the DNA repair gene Aplf in the fission-bearing species, which caused exon skipping and produced a truncated protein that...
Read the complete abstract on PubMedTopics
- Multiomics
- Chromosomes
- Animals
- Rodentia
- DNA-(Apurinic or Apyrimidinic Site) Lyase