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Article

Impact of VP2 mutations on viral fitness in canine parvovirus.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] - 27 Jul 2026

Lopes Tamiris Silva, Gheno Brenda Picoli, Wahed Ahmed Abd El, Truyen Uwe, Streck André Felipe

Abstract excerpt

Canine parvovirus type 2 (CPV-2) is a highly contagious pathogen responsible for severe gastroenteritis in carnivores, particularly in dogs. Continuous antigenic evolution has resulted in the emergence of CPV-2a, CPV-2b, and CPV-2c variants, defined by amino acid substitutions in the VP2 capsid protein. In this study, genetically altered CPV-2 viruses carrying common VP2 mutations (S297A, V300G, D305Y, Y324I,...

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Topics

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42507265
DOI: 10.1007/s42770-026-02035-2
PMCID: PMC13407408

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