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Metabolomics reveal distinct molecular pathways associated with future risk of Crohn’s Disease

5 Sept 2025

Abstract excerpt

Host - microbiome interactions are central to Crohn'sdisease (CD) pathogenesis; yet the early metabolic alterations that precededisease onset remain poorly defined. To explore preclinical metabolicsignatures of CD, we analyzed baseline serum metabolomic profiles in a nestedcase-control study within the Crohn's and Colitis Canada - Genetics, Environment, Microbiome (CCC-GEM) Project, a prospective cohort of 5,122...

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PMID: 40910526
DOI: 10.1080/19490976.2025.2546998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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