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Article

Relationship between affected family members and clinical aggressiveness in Familial non-medullary thyroid carcinoma: a systematic review and meta-analysis.

Endocrine - 1 Dec 2025

Yang Guang, Tian Ye, Zhang Yujie, Ran Yanhao, Fan Yuanyuan, Li Pengyu, Zheng Xun, Wei Tao

Abstract excerpt

PURPOSE: The clinical implications of the number of affected family members in familial non-medullary thyroid carcinoma (FNMTC) remain debated. This meta-analysis aimed to clarify whether families with ≥ 3 affected first-degree relatives (FNMTC-3) exhibit distinct clinicopathologic and prognostic features compared to families with two affected members (FNMTC-2), and to compare these patients with sporadic...

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PMID: 40908394
DOI: 10.1007/s12020-025-04413-6

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