Article
Familial non-medullary thyroid carcinoma displays the features of clinical anticipation suggestive of a distinct biological entity.
Endocrine-related cancer - 1 Dec 2008
Capezzone M, Marchisotta S, Cantara S, Busonero G, Brilli L, Pazaitou-Panayiotou K, Carli A F, Caruso G, Toti P, Capitani S, Pammolli A, Pacini F
Abstract excerpt
Non-medullary thyroid carcinoma (NMTC) is mostly sporadic, but familial clustering is described. We aimed to compare the features of patients with sporadic and familial NMTC (FNMTC) patients and to assess whether FNMTC patients with parent-child relationship exhibit the 'anticipation' phenomenon (earlier age at disease onset and increased severity in successive generations). Among 300 NMTCs followed in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.