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Article

Genotype for hypocretin receptor (hcrtr2) affects appetite in zebrafish.

General and comparative endocrinology - 1 Oct 2025

Lewandowski Nathan, Brainard Miranda, Kalb Chelsea, Wong Ashley, Liu Qin, Londraville Richard

Abstract excerpt

We investigated the role of hypocretin receptor in signaling appetite in zebrafish (Danio rerio). Hypocretin is a small neuropeptide known for its effects on circadian rhythm and appetite. Wild-type and heterozygous hu2098 (knockout for hcrtr2) zebrafish were raised to adulthood (3-4 months post fertilization) and genotyped. Feeding rate was measured directly using a novel technique that analyzed images of fish...

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Zebrafish Proteins
Appetite
Feeding Behavior
Genotype
Orexin Receptors

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PMID: 40907800
DOI: 10.1016/j.ygcen.2025.114808
PMCID: PMC13334432

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