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Article

Repeated intravenous transplantation of human umbilical cord mesenchymal stem cells does not promote tumorigenesis in EGFR-mutated lung cancer mice.

Stem cells translational medicine - 24 Jul 2025

Zhang Zepeng, Xu Anhua, Zhou Qian, Wen Fei, Chen Fenghua, Chen Hansen, Wang Hu, Chen Liang, Ju Zhenyu, Ge Yuanlong

Abstract excerpt

Mesenchymal stem cells (MSCs) are extensively studied in clinical trials for their potential therapeutic applications in degenerative and inflammatory diseases and disorders. Despite the lack of clinical evidence indicating that MSCs induce carcinogenesis, the immunosuppressive and proangiogenic functions of MSCs are considered as potential risks involving immune escape and tumor occurrence in programming tumor...

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Identifiers

PMID: 40892007
DOI: 10.1093/stcltm/szae065
PMCID: PMC12403704

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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