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Article

MED12-STAT1-TAP2 axis regulates CD8 + T cell cytotoxicity and mediates immunotherapy outcome in non-small cell lung cancer

1 Sept 2025

Abstract excerpt

Although immunotherapy for late-stage non-small cell lung carcinoma (NSCLC) has been clinically utilized, its prognosis remains highly heterogeneous, prompting us to investigate novel predictive immunotherapy biomarkers for NSCLC. We analyzed the correlations between MED12 nonsynonymous mutations and survival, clinical, genomic, transcriptomic information, and immune infiltration information through data mining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40888963
DOI: 10.1007/s10142-025-01690-2

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