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Article

CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer

29 Aug 2025

Abstract excerpt

Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, plays a crucial role in colorectal cancer progression and therapeutic response. The nuclear factor erythroid 2-related factor 2 (NRF2) pathway is one of the critical axes in ferroptosis regulation, which governs oxidative stress resistance and iron homeostasis through its downstream targets, including heme oxygenase 1...

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PMID: 40882016
DOI: 10.1158/0008-5472.can-24-4949

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CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal CancerPMID 40882016Read ↗

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