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Gut Microbiota and Its Metabolites Modulate Pregnancy Outcomes by Regulating Placental Autophagy and Ferroptosis

7 Aug 2025

Abstract excerpt

During pregnancy, the regulation of autophagy and ferroptosis dynamically supports placental development and fetal health. Both processes-autophagy, clearing damaged organelles to maintain placental function, and ferroptosis, driven by iron-dependent lipid peroxidation-are involved in pathological conditions such as preeclampsia. Emerging evidence suggests that gut microbiota-derived metabolites act as key...

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PMID: 40867866
DOI: 10.3390/antiox14080970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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