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Exploring the role of consanguinity in thalassemia prevalence in Pakistan: an in-depth analysis of genetic and cultural factors affecting public health

26 May 2025

Abstract excerpt

Thalassemia syndromes, inherited disorders marked by reduced hemoglobin production, pose a significant global health challenge, particularly in regions with high rates of consanguineous marriages. α- and β-Thalassemia vary in severity, ranging from asymptomatic carriers to severe anemia requiring lifelong transfusions. Consanguinity, common in areas like Southeast Asia, the Mediterranean, and Africa,...

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PMID: 40851932
DOI: 10.1097/ms9.0000000000003404

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