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Article

Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women.

Journal of translational medicine - 3 Sept 2018

Alemán José O, Bokulich Nicholas A, Swann Jonathan R, Walker Jeanne M, De Rosa Joel Correa, Battaglia Thomas, Costabile Adele, Pechlivanis Alexandros, Liang Yupu, Breslow Jan L, Blaser Martin J, Holt Peter R

Abstract excerpt

BACKGROUND: Microbiota and bile acids in the gastrointestinal tract profoundly alter systemic metabolic processes. In obese subjects, gradual weight loss ameliorates adipose tissue inflammation and related systemic changes. We assessed how rapid weight loss due to a very low calorie diet (VLCD) affects the fecal microbiome and fecal bile acid composition, and their interactions with the plasma metabolome and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30176893
DOI: 10.1186/s12967-018-1619-z
PMCID: PMC6122649

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