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Use of Machine Learning to Derive Discrete Clinical Phenotypes and Assess Treatment-Effect Heterogeneity in the Steroids in Cardiac Surgery Trial Dataset.

Anesthesia and analgesia - 1 May 2026

Duncan Andra E, Shah Karan, Yan Manshu, Kumar Nakul S, Sessler Daniel I, Whitlock Richard P

Abstract excerpt

BACKGROUND: Robust clinical trial data provide a key component for the development of evidence-informed medicine. However, clinical trial data may demonstrate treatment-effect heterogeneity, where some patients benefit from an intervention while others receive no benefit or perhaps even harm. If so, targeted therapy or a "personalized medicine" approach could provide treatment to a certain patient subset, that...

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PMID: 40828686
DOI: 10.1213/ANE.0000000000007715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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