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Article

Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis

16 Aug 2025

Abstract excerpt

Cholecystectomy represents the most prevalent biliary surgical procedure for gallbladder abnormalities. Growing evidence suggests that cholecystectomy is associated with an elevated risk of colorectal cancer. However, the underlying mechanism remains elusive. Here we show that cholecystectomy exacerbates colorectal tumorigenesis in both AOM/DSS and APCmin/+ mice models. Metagenomic sequencing and targeted...

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PMID: 40819131
DOI: 10.1038/s41467-025-62956-8

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