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Genetic Epidemiological Analysis of the Keratoconus Genetic Model in the Chinese Keratoconus Cohort Study.

Investigative ophthalmology & visual science - 1 Aug 2025

Yin Shanshan, Xu Liyan, Yang Kaili, Fan Qi, Gu Yuwei, Yin Chenchen, Zang Yonghao, Wang Yifan, Yuan Yi, Chang Anqi, Li Changxiu, Pang Chenjiu, Sahebjada Srujana, Hao Yibin, Ren Shengwei

Abstract excerpt

Purpose: Keratoconus (KC) is a corneal disorder characterized by progressive corneal protrusion and thinning. Our previous studies have demonstrated that genetic factors influence KC occurrence. The purpose of this study was to explore the genetic model of KC from the perspective of genetic epidemiology. Methods: A total of 157 KC families, including 157 KC probands and their 445 first-degree relatives, from the...

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Identifiers

PMID: 40793856
DOI: 10.1167/iovs.66.11.30
PMCID: PMC12364013

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