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Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting

8 Aug 2025

Abstract excerpt

Streptococcus pyogenes leads to 500,000 deaths annually, many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine development. Here we describe the evolution of serological profiles to conserved vaccine antigens and serotype-specific M proteins from birth and throughout the life course in The Gambia. As placentally transferred...

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PMID: 40781379
DOI: 10.1038/s41591-025-03868-4

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