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Can Family Motivation Enhance Men's Uptake of Cascade Screening for Familial BRCA1/2 Mutations?

American journal of men's health - 1 Jan 2025

Ongaro Giulia, Petrocchi Serena, Calvello Mariarosaria, Bonanni Bernardo, Feroce Irene, Pravettoni Gabriella

Abstract excerpt

Pathogenic variants in the BRCA1 and BRCA2 genes increase the relative and absolute risks of developing breast, ovarian, prostate, and pancreatic cancer. Clinical guidelines recommend cascade screening (CS) to enhance the identification of at-risk relatives. Despite the benefits of CS in facilitating access to appropriate cancer screening and risk-reduction strategies, CS uptake remains relatively low,...

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Identifiers

PMID: 40772289
DOI: 10.1177/15579883251343962
PMCID: PMC12332350

Genes

CS
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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