Application of machine learning algorithm for the prediction of lupus nephritis using SNP data, polygenic risk score, and electronic health record.

doi:10.1177/14604582251363510

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Article

Application of machine learning algorithm for the prediction of lupus nephritis using SNP data, polygenic risk score, and electronic health record.

Health informatics journal - 1 Jan 2025

Chung Chih-Wei, Chou Seng-Cho, Kao Chung-Mao, Chen Yen-Ju, Hsiao Tzu-Hung, Chen Yi-Ming

Abstract excerpt

BACKGROUND: Lupus nephritis (LN) flares raise the risks of renal failure and mortality in systemic lupus erythematosus (SLE) patients, making risk stratification and individualized care crucial. Our goal was to develop machine learning (ML) models to predict LN flares. METHODS: A total of 1546 SLE patients were enrolled from a hospital-based cohort. Electronic health record (EHR), single nucleotide polymorphism...

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PMID: 40767469
DOI: 10.1177/14604582251363510

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