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Article

Revisionist history uncovers a simplified molecular-based classification of differentiated thyroid cancer.

The Journal of pathology - 1 Oct 2025

Asa Sylvia L, Baloch Zubair, Jung Chan Kwon, Cipriani Nicole A, Gamboa-Domínguez Armando, Juhlin C Christofer, Riddle Nicole D, Stojanov Ivan J, Mete Ozgur

Abstract excerpt

The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes. However, molecular studies have revealed a simpler and less controversial approach, categorizing these lesions into RAS-like and BRAF p.V600E-like neoplasms. In this...

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Identifiers

PMID: 40762994
DOI: 10.1002/path.6456
PMCID: PMC12438045

Genes

BRAF

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