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Article

Trade-off between antibacterial immune defense and oogenesis progression in female Drosophila melanogaster.

Genetics - 8 Oct 2025

Gordon Kathleen E, Ray Shravasti, Marcin Jeremy M, Gonzales Patrick M, Li Mona L, Liang Crystal, Wolfner Mariana F, Lazzaro Brian P

Abstract excerpt

Trade-offs between reproduction and immunity are common in animals, potentially due to preferential allocation of limiting resources. In Drosophila melanogaster, mating stimulates egg production but also triggers a rapid and persistent decrease in female immune defense. Proteins essential for both processes are produced in fat body tissue, which may result in competition for cellular resources that could drive a...

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PMID: 40746174
DOI: 10.1093/genetics/iyaf151
PMCID: PMC12505294

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