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Article

The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.

Development (Cambridge, England) - 1 Aug 2025

Spitzer Danielle C, Sun William Y, Rodríguez-Vargas Anthony, Hariharan Iswar K

Abstract excerpt

The growth and survival of cells depends both on their intrinsic properties and interactions with their neighbors. In a screen of genes encoding cell-surface proteins for knockdowns that affect clone size or shape in mosaic Drosophila imaginal discs, we found that clones with reduced echinoid (ed) function are fewer and smaller, and are frequently eliminated during development. This elimination results, in...

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Identifiers

PMID: 40689564
DOI: 10.1242/dev.204572
PMCID: PMC12377819

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