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Ciprofol suppresses glycolysis and EMT in colorectal cancer cells by activating APC to modulate the Wnt/β-catenin signaling pathway

20 Jul 2025

Abstract excerpt

Ciprofol, an innovative anesthetic derived from propofol, has not yet been studied in detail regarding its effects in colorectal cancer (CRC). This study mainly explored the effects of Ciprofol on the epithelial-mesenchymal transition (EMT) process, glycolysis, and the Wnt/β-catenin signaling pathway in CRC cells. Through in vitro and in vivo experiments, we successfully demonstrated that Ciprofol can inhibit the...

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PMID: 40685385
DOI: 10.1038/s41598-025-08652-5

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