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Biomarkers for Alzheimer’s disease across diverse biological domains: an umbrella review and evidence map

17 Jul 2025

Abstract excerpt

• Review of 35 meta -analyses involving over 156,161 participants identified 106 candidate biomarkers for Alzheimer’s disease. • A total of 52 biomarkers were statistically significant, with 26 exhibiting high credibility. • The findings advocate a multimodal biomarker approach to enhance early diagnosis and monitoring of Alzheimer’s disease. • Non-invasive assays based on urine, saliva, and plasma are...

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PMID: 40680830
DOI: 10.1016/j.jare.2025.07.022

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