Article
Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group.
The Lancet. Neurology - 1 Jun 2021
Dubois Bruno, Villain Nicolas, Frisoni Giovanni B, Rabinovici Gil D, Sabbagh Marwan, Cappa Stefano, Bejanin Alexandre, Bombois Stéphanie, Epelbaum Stéphane, Teichmann Marc, Habert Marie-Odile, Nordberg Agneta, Blennow Kaj, Galasko Douglas, Stern Yaakov, Rowe Christopher C, Salloway Stephen, Schneider Lon S, Cummings Jeffrey L, Feldman Howard H
Abstract excerpt
In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a purely biological definition of Alzheimer's disease that relies on biomarkers. Although the intended use of this framework was for research purposes, it has engendered debate and challenges regarding its use in everyday clinical practice. For instance, cognitively unimpaired individuals can have biomarker evidence of both...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Biomarkers
- Cognitive Dysfunction
- Disease Progression
- Humans
- Phenotype
- tau Proteins