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Article

Deciphering TLR and JAK/STAT pathways: genetic variants and targeted therapies in COVID-19.

Molecular biology reports - 18 Jul 2025

El Houdi Meriem, Skhoun Hanaa, Guennoun Aya, Dakka Nadia, Ameziane El Hassani Rabii, Ouzzif Zohra, El Baghdadi Jamila

Abstract excerpt

Genetic alterations affecting the immune-related pathways can significantly disrupt the innate immune system among patients with COVID-19, contributing to disease severity. Research investigations have shown that common or rare mutations in TLR genes, mainly TLR3 and TLR7, can impair the recognition of viral RNA, leading to an altered interferon response. Moreover, the NF-κB pathway, which represents a vital...

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Identifiers

PMID: 40679664
DOI: 10.1007/s11033-025-10843-2

Genes

TLR3
TLR7

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