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Article

Genetic and phenotypic links between obesity and extracellular vesicles.

Human molecular genetics - 28 Oct 2022

Zhai Ranran, Pan Lu, Yang Zhijian, Li Ting, Ning Zheng, Pawitan Yudi, Wilson James F, Wu Di, Shen Xia

Abstract excerpt

Obesity has a highly complex genetic architecture, making it difficult to understand the genetic mechanisms, despite the large number of discovered loci via genome-wide association studies (GWAS). Omics techniques have provided a better resolution to view this problem. As a proxy of cell-level biology, extracellular vesicles (EVs) are useful for studying cellular regulation of complex phenotypes such as obesity....

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PMID: 35357430
DOI: 10.1093/hmg/ddac069
PMCID: PMC9616576

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