Article
α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2025
Jacob Anand, Willet Alaina H, Igarashi Maya G, El Hariri El Nokab Mustapha, Turner Lesley A, Alsanad Abdulrahman Khalid A, Wang Tuo, Gould Kathleen L
Abstract excerpt
Cell walls are critical structures of fungi, bacteria, and plants, providing mechanical strength, maintaining shape, and protecting cells from environmental stress. In the fission yeast Schizosaccharomyces pombe, the α-glucan synthase Ags1 produces α-1,3-glucan chains essential for cell wall integrity, but how these chains are further assembled into mature polymers is not understood. Here, we identify two...
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