Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer.

doi:10.1002/ijc.70035

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Article

Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer.

International journal of cancer - 1 Nov 2025

Ruggiero Raffaella, Ottaiano Alessandro, Tathode Madhura, Sirica Roberto, Di Mauro Annabella, Ianniello Monica, Petrillo Nadia, Berretta Massimiliano, Zappavigna Silvia, Luce Amalia, Caraglia Michele, Savarese Giovanni

Abstract excerpt

Evidence suggests that metastatic colorectal cancer patients with type 2 diabetes (T2D) experience a poorer prognosis in contrast to their non-diabetic counterparts. Considering the multifactorial genetic nature of colon cancer development, we examined whether gene polymorphisms associated with T2D could affect the clinical outcome of metastatic colon cancer. Using in silico analysis, we evaluated gene variants...

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