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Fisetin limits Chikungunya virus-induced apoptosis hallmarks in hepatocellular carcinoma cells

11 Jul 2025

Abstract excerpt

The study investigated the protective effects of fisetin on chikungunya virus (CHIKV)-induced apoptosis hallmarks in Huh7 cells. Fisetin significantly reduced CHIKV RNA levels and viral infectivity, outperforming Z-VAD-FMK and cisplatin. At 30 µM, fisetin markedly decreased (by > 90%) the number of infectious viral particles at 24 and 48 h post-infection (hpi). Fisetin also hindered CHIKV-induced DNA...

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PMID: 40645991
DOI: 10.1038/s41598-025-09213-6

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