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Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

11 Jul 2025

Abstract excerpt

Respiratory syncytial virus (RSV) is a significant cause of morbidity and mortality in high-risk populations. Although prophylactic options are available, there are no effective oral therapeutics for RSV infection. Obeldesivir (ODV) is an orally bioavailable prodrug of the nucleoside analog GS-441524, which is converted intracellularly to its active nucleoside triphosphate and inhibits the RSV RNA polymerase....

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PMID: 40645925
DOI: 10.1038/s41467-025-61595-3

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