RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium subsp. paratuberculosis

Abstract excerpt

(MAP)-infected animals have identified a range of differentially expressed mRNAs with potential as biomarkers for MAP infection. As bioinformatic tools continue to develop, microRNAs (miRNAs) and alternative splicing (AS) have emerged as important contributors to host responses during infections. Although RNA-Seq enables AS analysis, most transcriptomic studies still emphasize gene-level expression due to the...

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