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Article

Inflammation-like environments limit the loss of quorum sensing in Pseudomonas aeruginosa.

mSystems - 19 Aug 2025

Fu Taoran, Wright Rosanna C T, Gifford Danna R, Knight Christopher G, Brockhurst Michael A

Abstract excerpt

Within-host environments are complex and multidimensional, making it challenging to link the evolutionary responses of colonizing pathogens to causal selective drivers. Loss of quorum sensing (QS) via mutation of the master regulator, lasR, is a common adaptation of Pseudomonas aeruginosa during chronic infections. Here, we use experimental evolution in host-mimicking media to show that loss of QS is constrained...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40621905
DOI: 10.1128/msystems.01722-24
PMCID: PMC12363187

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