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Influence of lifestyle risk factors and genetic predisposition on metabolic syndrome risk in Korean adults

5 Jul 2025

Abstract excerpt

Metabolic syndrome (MetS) is a major risk factor for cardiovascular and chronic diseases. This study evaluated how genetic predisposition and lifestyle factors contribute to MetS risk. We analysed data from 4,987 Koreans aged ≥ 40 years with at least one ASCVD risk factor (2014–2017). A polygenic risk score for metabolic disease (PRS MetS ) using eight metabolic phenotypes was used to categorise participants into...

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PMID: 40617926
DOI: 10.1038/s41598-025-07369-9

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