Article
Assessing germline mutational profile and its clinicopathological associations in Triple Negative Breast Cancer.
Cancer genetics - 1 Sept 2025
John Jisha, Bapat Ashwini, Gahlaut Siddharth, Luke Naveen, Kumar Rahul, Thakur Yashaswi, Mathew Christina, Konnur Aishwarya, Namewar Namrata, Reddy Ruhi, Nagarkar Sanket, Nare Smeeta, Thomas George, Busheri Laleh, Reddy Asha, Kelkar Devaki, Dixit Santosh, Deshmukh Chetan, Ul Mannan Ashraf, Sabarinathan Radhakrishnan, Radhakrishna Selvi, Mishra Rupa, Koppiker Chaitanyanand B
Abstract excerpt
BACKGROUND: Breast cancer is the most common cancer in Indian women with a high incidence of triple negative breast cancer (TNBC). The high TNBC prevalence (>25 %) in India remains a challenge in clinical management. Association of germline BRCA1/2 mutations in TNBCs is well-established as a predisposing factor for hereditary breast cancer risk. These studies are, however, predominantly representative of western...
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