Association of high-dose radioactive iodine therapy with PPM1D-mutated clonal hematopoiesis in older individuals.

doi:10.1002/1878-0261.70078

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Article

Association of high-dose radioactive iodine therapy with PPM1D-mutated clonal hematopoiesis in older individuals.

Molecular oncology - 1 Nov 2025

Kim Jaeryuk, Bae Sungwoo, Choi Jaeyong, Im Sun-Wha, Cha Bukyoung, Jung Gyeongseo, Cho Sun Wook, Seo Eul-Ju, Lee Young Ah, Paeng Jin Chul, Park Young Joo, Kim Jong-Il

Abstract excerpt

While radioactive iodine therapy (RAIT) has been an effective treatment for thyroid cancer, its link to clonal hematopoiesis (CH) has been yet underexplored. In this study, error-corrected sequencing (median depth: 1926×) of 93 CH-related genes was performed from the blood samples of 358 thyroid cancer patients, including 110 controls (no RAIT) and 248 RAIT recipients. RAIT recipients were stratified into low-...

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