Article
Radioactive Iodine-Related Clonal Hematopoiesis in Thyroid Cancer Is Common and Associated With Decreased Survival.
The Journal of clinical endocrinology and metabolism - 1 Nov 2018
Boucai Laura, Falcone John, Ukena Jenny, Coombs Catherine C, Zehir Ahmet, Ptashkin Ryan, Berger Michael F, Levine Ross L, Fagin James A
Abstract excerpt
Context: Radioactive iodine (RAI) has been epidemiologically associated with the development of hematologic malignancies. Clonal hematopoiesis (CH) is a precursor clonal state that confers increased risk of leukemia and occurs at an elevated rate in patients with thyroid cancer relative to other solid tumors. Objective: We explore if the high prevalence of CH may be a result of RAI exposure and whether CH may be...
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