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Article

How recombination and clonal evolution shape bacterial lineages and genomes.

Genetics - 12 Nov 2025

Preska Steinberg Asher, Kussell Edo

Abstract excerpt

Homologous recombination is a key process in bacterial genome evolution. By analyzing sequencing collections of 12 bacterial species encompassing >100,000 genomes, we determine how recombination and clonal evolution shape bacterial lineages and genome structures. Previous analyses proposed that for some bacterial species recombination is so dominant that almost no clonal genomic fraction remains. Further, it has...

Topics

Genome, Bacterial
Recombination, Genetic
Phylogeny
Polymorphism, Single Nucleotide
Clonal Evolution
Models, Genetic
Bacteria
Evolution, Molecular
Escherichia coli

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40554592
DOI: 10.1093/genetics/iyaf115
PMCID: PMC12606435

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